Dr McCombe is Clinical Director, Opthalmology Services, Consultant Ophthalmologist and retinal specialist in the surgical and medical retinal clinics here at The Royal Victorian Eye and Ear Hospital. He has a special interest in diabetic eye disease, eye trauma, age-related macula degeneration and vitreoretinal surgery. He is also currently Clinical Director of Ophthalmology at the Eye and Ear.

He is a co-author of the NHMRC Publication of Diabetic Eye Disease. He has been active in the affairs of RANZCO (Royal Australian and New Zealand College of Ophthalmologists), having been both a state and federal councillor and has been involved in the organisation of the RANZCO National Conference on a number of occasions.

Dr McCombe also has an interest in medico-legal work pertaining to ophthalmology and has undertaken the AMA Guidelines course for assessment of impairment. The Clinical Director, Ophthalmology Services is responsible for ophthalmology clinical and medical leadership. The role advises on models of care in ophthalmology that are sustainable and lead to excellence.